OLT1177 (Dapansutrile) inhibits Gasdermin D-dependent IL-1β Release and Pyroptotic Cell Death in Bone Marrow-derived Macrophages
Karl A. Pankratz, Masoom Raza, Jarren Ypil, Migachelle Banks, Carlo Marchetti, Tania Azam, Charles Anthony Dinarello, Shaikh Muhammad Atif
OLT1177 inhibits IL-1β release and pyroptotic cell death in LPS-treated BMDMs by blocking caspase-1 and GSDMD activation.
bioRxiv · Jun 3, 2026 · PreprintImmunology