Loss of Tsc1 in cerebellar Purkinje cells induces transcriptional and translation changes in FMRP target transcripts
Jasbir Singh Dalal, Kellen Diamond Winden, Catherine Lourdes Salussolia, Maria Sundberg, Achint K. Singh, Truc Thanh Pham, Pingzhu Zhou, William T. Pu, Meghan T. Miller, Mustafa Şahin
The paper investigates transcriptional and translational changes in Tsc1-deficient cerebellar Purkinje cells, finding reduced FMRP target transcripts with increased degradation and decreased SHANK2 levels in synapses.
eLife · Jul 14, 2021Peer-reviewedNeuroscience