Pingzhu Zhou

This paper designs AAV vectors with enhancer-controlled ITR promoters to improve payload capacity and enable tissue-specific gene editing with a single AAV.

This study identifies VGLL4 as a regulator of classical brown adipose tissue development by modulating the Hippo-YAP pathway and adipogenic gene expression.

The paper investigates transcriptional and translational changes in Tsc1-deficient cerebellar Purkinje cells, finding reduced FMRP target transcripts with increased degradation and decreased SHANK2 levels in synapses.

The paper shows that enhancer-dependence of gene expression increases with developmental age in mouse and human cells.