YAP signaling promotes resistance to MEK and AKT inhibition in NF1-related MPNSTs
Lauren E. McGee, Jamie L. Grit, Curt J. Essenburg, Sophia Agrusa, Elizabeth A. Tovar, Lisa Turner, Katelyn Becker, Jason Zbieg, Anwesha Dey, Jennifer E. Klomp, Jeffrey A. Klomp, Marie Adams, Ian Beddows, Emily Wolfrom, Zhen Fang Fu, , Matthew R. Steensma
This study identifies YAP signaling as a driver of resistance to MEK and AKT inhibitors in NF1-related MPNSTs using preclinical models and spatial transcriptomics.
bioRxiv · Jun 16, 2025 · PreprintCancer Biology