Author

Sophia Agrusa

Van Andel Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Carrie R. GraveeliD· 2 shared Emily WolfrumiD· 2 shared Ian BeddowsiD· 2 shared Marie AdamsiD· 2 shared Matthew R. SteensmaiD· 2 shared Angela C. HirbeiD· 1 shared Anwesha DeyiD· 1 shared Curt J. EssenburgiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Carrie R. GraveelORCID

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2 papers

Recent·Most cited

NF1 splicing reprograms ERα signaling to promote luminal breast cancer progression

Patrick S. Dischinger, Ian Beddows, Sophia Agrusa, Marie Adams, Emily Wolfrum, Carrie R. Graveel, Matthew R. Steensma

This paper identifies an alternatively spliced NF1 isoform, NLS SE, that promotes luminal breast cancer progression by disrupting nuclear neurofibromin function and reprogramming ER signaling toward post-transcriptional regulation.

bioRxiv · May 26, 2026 · PreprintCancer Biology

YAP signaling promotes resistance to MEK and AKT inhibition in NF1-related MPNSTs

Lauren E. McGee, Jamie L. Grit, Curt J. Essenburg, Sophia Agrusa, Elizabeth A. Tovar, Lisa Turner, Katelyn Becker, Jason Zbieg, Anwesha Dey, Jennifer E. Klomp, Jeffrey A. Klomp, Marie Adams, Ian Beddows, Emily Wolfrom, Zhen Fang Fu, , Matthew R. Steensma

This study identifies YAP signaling as a driver of resistance to MEK and AKT inhibitors in NF1-related MPNSTs using preclinical models and spatial transcriptomics.

bioRxiv · Jun 16, 2025 · PreprintCancer Biology