Upregulation of FasII underlies synergistic neuropathological and behavioral defects in a Drosophila model of myotonic dystrophy
Alex Chun Koon, Ka Yee Winnie Yeung, Lok I Leong, Zhefan Stephen Chen, Shaohong Isaac Peng, Joyce Man See Fung, Yitao Wu, Noah S. Armstrong, Ariadna Bargiela, Nerea Moreno, Javier Poyatos, Juan Jesus Vilchez, Paul Magneron, Aline Huguet-Lachon, Cassandra Kussius Brewer, , Ho Yin Edwin Chan
This study identifies FasII upregulation as a key factor in DM1 neuropathology using a Drosophila model, showing that manipulating FasII isoforms can rescue synaptic and behavioral defects.
bioRxiv · May 26, 2024 · PreprintNeuroscience