Author

Zhefan Stephen Chen

Chinese University of Hong KongORCID 0000-0002-9276-0378Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Organism:Drosophila· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Alex Chun KooniD· 1 shared Aline Huguet-LachoniD· 1 shared Ariadna BargielaiD· 1 shared Brian D. McCabeiD· 1 shared C. Andrew FrankiD· 1 shared Cassandra Kussius Brewer· 1 shared Erin BeckiD· 1 shared Geneviève GourdoniD· 1 shared

Activity by Year

2024-2024 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperNeuroscience

Alex Chun KoonORCID

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1 paper

Recent·Most cited

Upregulation of FasII underlies synergistic neuropathological and behavioral defects in a Drosophila model of myotonic dystrophy

Alex Chun Koon, Ka Yee Winnie Yeung, Lok I Leong, Zhefan Stephen Chen, Shaohong Isaac Peng, Joyce Man See Fung, Yitao Wu, Noah S. Armstrong, Ariadna Bargiela, Nerea Moreno, Javier Poyatos, Juan Jesus Vilchez, Paul Magneron, Aline Huguet-Lachon, Cassandra Kussius Brewer, , Ho Yin Edwin Chan

This study identifies FasII upregulation as a key factor in DM1 neuropathology using a Drosophila model, showing that manipulating FasII isoforms can rescue synaptic and behavioral defects.

bioRxiv · May 26, 2024 · PreprintNeuroscience