Aquaporin-4 mis-localization slows glymphatic clearance of α-synuclein and promotes α-synuclein pathology and aggregate propagation
Molly Braun, Matthew J. Simon, Jay Jang, Keith Sanderson, Justyna Swierz, Mathew Sevao, Alexandra B. Pincus, Allison J. Schaser, Jonathan E. Elliott, Miranda M. Lim, Vivek K. Unni, Abigail G. Schindler, Christopher Dirk Keene, Caitlin S. Latimer, Jeffrey J. Iliff
This study shows that AQP4 mis-localization impairs glymphatic clearance of α-synuclein and promotes its aggregation and spread in neurodegenerative diseases.
bioRxiv · Aug 14, 2024 · PreprintNeuroscience