Author
Columbia University Irving Medical Center
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
7 papers
Recent·Most cited
John F. Tuddenham, Masashi Fujita, Emily Lee…·Marta Olah
The paper identifies microglia subsets in ALS brain and spinal cord, finding an undifferentiated phenotype and enrichment of interferon response microglia in aggressive cases.
Cyril P. Pottier, Fahri Küçükali, Matt C. Baker…·Edward B. Lee
This study identifies genetic risk factors for FTLD-TDP subtypes using whole-genome sequencing and meta-analysis across multiple cohorts.
Yiyi Ma, Dolly Reyes‐Dumeyer, Angel L. Piriz…·Badri Narayan Vardarajan
The paper identifies six genetic loci associated with Alzheimer's disease in Hispanics, showing both genetic and epigenetic risks, with some downstream effects on mRNA expression being ethnicity-specific.
Fahad Paryani, Ji‐Sun Kwon, Chris W Ng…·Osama Al‐Dalahmah
This study uses multi-omic analysis to identify a neuroprotective astrocyte state in Huntington disease that correlates with delayed disease onset and neuroprotection.
Ryan G. Lim, Osama Al‐Dalahmah, Jie Wu…·Leslie Michels Thompson
This study uses snRNAseq to analyze HD mouse models and human brain tissue, identifying impaired oligodendrocyte maturation and a potential role for thiamine metabolism in disease pathology.
Osama Al‐Dalahmah, Alexander A. Sosunov, A Shaik…·James E. Goldman
This study uses snRNA-seq to identify distinct transcriptional states of astrocytes in Huntington disease, revealing gene expression changes compared to controls.
Natalie Ellis, Amelia Tee, Branduff McAllister…·Peter Holmans
The paper investigates genetic risk factors for psychiatric and cognitive symptoms in Huntington’s Disease using polygenic risk scores and finds associations between specific psychiatric risk scores and corresponding symptoms.