Author

Ji‐Sun Kwon

Washington University in St. Louis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:differential expression· 3 Approach:experimental assay· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 1 Research Focus:database / resource· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Andrew S.J. YooiD· 4 shared Juncheng LiiD· 2 shared Osama Al‐DalahmahiD· 2 shared Aayushi MahajaniD· 1 shared Alice Tang· 1 shared Anna Okula BasileiD· 1 shared Caitlin McHughiD· 1 shared Celeste M M. KarchiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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4 shared papersNeuroscience

Andrew S.J. YooORCID

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4 papers

Recent·Most cited

The human-specific lncRNA HD-LINC drives lipid droplet-associated neurodegeneration in Huntington's disease

Ji‐Sun Kwon, Liyuan Wang, Naga R. Ganti, Juncheng Li, Shengnan Xia, Osama Al‐Dalahmah, Andrew S.J. Yoo

This study identifies HD-LINC, a human-specific lncRNA, as a driver of lipid droplet-associated neurodegeneration in Huntington's disease, showing its role in lipid metabolism and neuronal death.

bioRxiv · Oct 27, 2026 · PreprintNeuroscience

Sequelae and reversal of age-dependent alterations in mitochondrial dynamics via autophagy enhancement in reprogrammed human neurons

Eva Klinman, Ji‐Sun Kwon, Roland E. Dolle, Stephen C. Pak, Gary A. Silverman, David H. Perlmutter, Andrew S.J. Yoo

This study investigates age-related changes in mitochondrial dynamics and autophagy in reprogrammed human neurons, finding that autophagy enhancement can reverse these age-dependent alterations.

bioRxiv · Oct 2, 2025 · PreprintNeuroscience

Endogenous recapitulation of Alzheimers disease neuropathology through human 3D direct neuronal reprogramming

Zhao Qing Sun, Ji‐Sun Kwon, Yudong Ren, Shawei Chen, Kitra Cates, Xinguo Lu, Courtney K. Walker, Hande Karahan, Sanja Sviben, James A. J. Fitzpatrick, Clarissa Valdez, Henry Houlden, Celeste M M. Karch, Randall John Bateman, Chihiro Sato, , Andrew S.J. Yoo

This study uses 3D direct neuronal reprogramming of AD patient fibroblasts to recapitulate AD neuropathology, showing A{beta} deposition, tauopathy, and neuronal death, and identifies potential therapeutic targets.

Science · Aug 1, 2024Peer-reviewedNeuroscience

Multi-OMIC analysis of Huntington disease reveals a neuroprotective astrocyte state

Fahad Paryani, Ji‐Sun Kwon, Chris W Ng, Nacoya Madden, Kenneth Ofori, Alice Tang, Hong Lü, Juncheng Li, Aayushi Mahajan, Shawn M. Davidson, Anna Okula Basile, Caitlin McHugh, Jean Paul Vonsattel, Richard A. Hickman, Michael C. Zody, , Osama Al‐Dalahmah

This study uses multi-omic analysis to identify a neuroprotective astrocyte state in Huntington disease that correlates with delayed disease onset and neuroprotection.

bioRxiv · Sep 8, 2023 · PreprintNeuroscience