James E. Goldman

The paper analyzes T-cell responses and glial pathology in Parkinson's disease substantia nigra using single nucleus RNA sequencing and spatial transcriptomics, revealing CD8+ T-cell characteristics and altered cellular interactions.

This study uses multi-omic analysis to identify a neuroprotective astrocyte state in Huntington disease that correlates with delayed disease onset and neuroprotection.

This study identifies border-associated macrophages (BAMs) as key mediators of alpha-synuclein-induced neuroinflammation in Parkinson's disease.

This study uses snRNAseq to analyze HD mouse models and human brain tissue, identifying impaired oligodendrocyte maturation and a potential role for thiamine metabolism in disease pathology.

This study identifies TMEM106B as an insoluble protein increased in MS plaques and shows its deletion causes axonal damage and lipid accumulation in demyelination models.

This study identifies nuclear architecture disruption as a mechanism underlying SARS-CoV-2 induced anosmia by analyzing human and hamster olfactory tissues.

This study investigates the impact of propionic acidemia on astrocytes, finding minimal alterations in both in vitro and in vivo models, suggesting astrocytes may not be a primary target for therapy.

This study uses snRNA-seq to identify distinct transcriptional states of astrocytes in Huntington disease, revealing gene expression changes compared to controls.