A defining member of the new cysteine-cradle family is an aECM protein signalling skin damage in C. elegans
Thomas Sonntag, Shizue Omi, Antonina E. Andreeva, Claire Valotteau, Jeanne Eichelbrenner, Andrew D. Chisholm, Jordan D. Ward, Nathalie Pujol
The paper identifies spia-1 as a gene involved in immune activation in C. elegans by sensing cuticle damage through its secreted protein with a novel cysteine-cradle domain.
PLoS Genetics · Mar 20, 2025Peer-reviewedDevelopmental Biology