Andrew D. Chisholm

The paper develops a toolkit for fluorescently tagging apical extracellular matrix components in C. elegans to study their molecular architecture and spatial organization.

The paper identifies spia-1 as a gene involved in immune activation in C. elegans by sensing cuticle damage through its secreted protein with a novel cysteine-cradle domain.

The paper investigates the role of lipid metabolism in axon maintenance and regeneration in C. elegans, showing that DIP-2 counterbalances phospholipid synthesis to prevent age-related axonal defects.

This study identifies the localization and function of C. elegans epicuticlins in the apical extracellular matrix, showing their role in wound repair.

The paper identifies a network involving DIP-2, SAX-2, PAD-1, and TAT-5 that regulates neuronal morphology by controlling extracellular vesicle release in C. elegans.

This paper shows that NHR-23 is essential for C. elegans development and apical extracellular matrix structure by regulating gene expression in seam and hypodermal cells.

The paper shows that juvenile C. elegans generate symmetric motor patterns through an asymmetric motor circuit, with dorsal bending driven by synaptic wiring and ventral bending via extrasynaptic signaling from premotor interneurons.

The paper reconstructs the post-embryonic maturation of the C. elegans motor circuit using electron microscopy, showing how structural rewiring maintains functional output during development.

This study uses connectomics to show how brain circuits change with age in C. elegans, revealing principles of brain maturation through structural and functional remodeling.

This study investigates the tissue-specific functions of C. elegans JPH-1, showing its role in neurotransmission and muscle contraction, and its interaction with calcium channels.

The paper describes a method for tissue-specific protein degradation in C. elegans using a GFP-targeting nanobody fused to a ubiquitin ligase adaptor, enabling efficient ablation of GFP-tagged proteins in multiple tissues.