Tumor-draining lymph node derived CD8 T cells sustain durable systemic immunity after neoadjuvant IL-15 and PD-1 blockade
Tatiana Cruz, Rachel Honigsberg, Geoffrey J. Markowitz, Dicle Özge Özgenel, Arshdeep Singh, Meixian Stephanie Tang, Stella A. Martomo, Liron Yoffe, Yongfeng He, Yang Bai, Jeegar P. Patel, Marissa M. Michael, Mitchell T. Martin, Timothy E. McGraw, Olivier Elemento, , Jonathan Villena‐Vargas
Neoadjuvant IL-15 with PD-1 blockade expands lymph node clonal diversity and preserves stem-like CD8 T cell features, yielding superior antitumor efficacy, durable memory, and reduced metastatic recurrence.
bioRxiv · Aug 12, 2025 · PreprintImmunology