Adelheid M. Lempradl

This study shows that mutating the white gene in Drosophila causes widespread transcriptomic and phenotypic changes beyond eye pigmentation, highlighting the need for genetic background control.

This study investigates the metabolic effects of low-dose benzene exposure in mice, finding mitochondrial dysfunction and dose-dependent changes in metabolic pathways.

This study develops a single-embryo metabolomics method to analyze metabolic and transcriptional changes in early Drosophila embryos with high temporal resolution.

This paper presents a single-embryo RNA-sequencing method to analyze early Drosophila gene expression, revealing transcription start times, degradation patterns, and sex-biased transcription.

This study shows that prenatal benzene exposure alters hypothalamic development in male offspring, leading to metabolic dysregulation and increased susceptibility to metabolic disease later in life.

This study shows that paternal dietary sugar affects offspring gene expression through sperm piRNA pathways, linking small RNA regulation to intergenerational epigenetic inheritance.

This study identifies 15 common and 9 low-frequency protein-coding variants associated with body fat distribution, implicating novel genes related to lipid homeostasis and type 2 diabetes.

This study identifies chromatin-state signatures linked to β-cell dysfunction and diabetes by combining epigenome mapping with single-cell transcriptomics in mice and humans.