The constitutive androstane receptor protects against metabolic dysfunction-associated steatotic liver disease through sex specific interactions with the gut microbiota
Marine Huillet, Céline M P Martin, Guillaume Magne, Frédèric Lasserre, Justine Bruse, Valérie Alquier‐Bacquie, Arnaud Polizzi, Clémence Rives, Prunelle Perrier, Noémie Poirier-Jaouen, Sarra Smati, Géraldine Garcia, Jelskey Gomes, Elodie Rousseau-Bacquié, Claire Naylies, , Sandrine Ellero‐Simatos
This study shows that the constitutive androstane receptor (CAR) protects against MASLD in males through interactions with gut microbiota, but not in females.
bioRxiv · Oct 11, 2026 · PreprintPhysiology