Valérie Alquier‐Bacquie

The constitutive androstane receptor protects against metabolic dysfunction-associated steatotic liver disease through sex specific interactions with the gut microbiota

This study shows that the constitutive androstane receptor (CAR) protects against MASLD in males through interactions with gut microbiota, but not in females.

Diet modulates metabolic and hepatic responses to chronic pesticide mixture exposure in mice

This study shows that dietary context affects the metabolic effects of pesticide mixtures in mice, exacerbating glucose intolerance and insulin resistance on a western diet.

Soluble and insoluble dietary fibres differentially affect liver steatosis and gut microbiota in western-diet fed mice

This study shows that soluble fiber inulin reduces liver fat and metabolic issues in mice on a Western diet, while insoluble fiber cellulose does not, suggesting inulin's benefits come from its effect on gut microbiota.

Hepatocyte FGF21 is not required for fasting-induced metabolic responses but guides protein appetite after energy depletion

Effect of thermoneutral housing on MASLD severity, hepatic gene expression, and BAT activation during β3-adrenergic stimulation in mice

This study shows thermoneutral housing worsens MASLD in mice by increasing obesity, inflammation, fibrosis, and impairing BAT activation during β3-adrenergic stimulation.