Sandrine Ellero‐Simatos

Dietary fructose promotes anxiety through impairment of microglia physiology

This study shows that dietary fructose causes anxiety by impairing microglia function, with sex-specific effects on metabolism and behavior.

The constitutive androstane receptor protects against metabolic dysfunction-associated steatotic liver disease through sex specific interactions with the gut microbiota

This study shows that the constitutive androstane receptor (CAR) protects against MASLD in males through interactions with gut microbiota, but not in females.

Environmentally relevant bisphenol mixtures modify heart-brain physiology, cerebrovascular structures, and transcriptomic profiles in zebrafish larvae

PPARα-dependent effects in the liver and jejunum of mice in response to pemafibrate

This study examines pemafibrate's tissue-specific transcriptional effects in PPAR-dependent mice, showing strong responses in liver and jejunum but not in other tissues.

Diet modulates metabolic and hepatic responses to chronic pesticide mixture exposure in mice

This study shows that dietary context affects the metabolic effects of pesticide mixtures in mice, exacerbating glucose intolerance and insulin resistance on a western diet.

Soluble and insoluble dietary fibres differentially affect liver steatosis and gut microbiota in western-diet fed mice

This study shows that soluble fiber inulin reduces liver fat and metabolic issues in mice on a Western diet, while insoluble fiber cellulose does not, suggesting inulin's benefits come from its effect on gut microbiota.

Hepatocyte FGF21 is not required for fasting-induced metabolic responses but guides protein appetite after energy depletion

Maternal diet alters offspring early life host-microbiota communication through goblet cells, resulting in long-lasting diseases susceptibility

This study shows maternal diet affects offspring microbiota and health through goblet cells, leading to long-term disease susceptibility.

Effect of thermoneutral housing on MASLD severity, hepatic gene expression, and BAT activation during β3-adrenergic stimulation in mice

This study shows thermoneutral housing worsens MASLD in mice by increasing obesity, inflammation, fibrosis, and impairing BAT activation during β3-adrenergic stimulation.