Claire Naylies

The constitutive androstane receptor protects against metabolic dysfunction-associated steatotic liver disease through sex specific interactions with the gut microbiota

This study shows that the constitutive androstane receptor (CAR) protects against MASLD in males through interactions with gut microbiota, but not in females.

PPARα-dependent effects in the liver and jejunum of mice in response to pemafibrate

This study examines pemafibrate's tissue-specific transcriptional effects in PPAR-dependent mice, showing strong responses in liver and jejunum but not in other tissues.

Diet modulates metabolic and hepatic responses to chronic pesticide mixture exposure in mice

This study shows that dietary context affects the metabolic effects of pesticide mixtures in mice, exacerbating glucose intolerance and insulin resistance on a western diet.

Genetic and heat-stress related environmental influences on pig whole-blood gene expression levels

The paper investigates the genetic and heat-stress environmental influences on gene expression in pigs, identifying differentially expressed genes, eQTLs, and candidate genes for traits like backfat thickness.

Hepatocyte ERα orchestrates sex-specific liver adaptation to fasting and feeding states

This study shows hepatocyte ERα regulates sex-specific liver responses to fasting and feeding, affecting gene expression and metabolic pathways differently in males and females.

Soluble and insoluble dietary fibres differentially affect liver steatosis and gut microbiota in western-diet fed mice

This study shows that soluble fiber inulin reduces liver fat and metabolic issues in mice on a Western diet, while insoluble fiber cellulose does not, suggesting inulin's benefits come from its effect on gut microbiota.

Hepatocyte FGF21 is not required for fasting-induced metabolic responses but guides protein appetite after energy depletion

Effect of thermoneutral housing on MASLD severity, hepatic gene expression, and BAT activation during β3-adrenergic stimulation in mice

This study shows thermoneutral housing worsens MASLD in mice by increasing obesity, inflammation, fibrosis, and impairing BAT activation during β3-adrenergic stimulation.