Decoding Lymphangioleiomyomatosis (LAM) Niche Environment via Integrative Analysis of Single Cell Multiomics and Spatial Transcriptomics
Ken Chen, Shuyang Zhao, Minzhe Guo, Hasan Reza, Andrew Wagner, Adnan Cihan Cakar, Cheng Jiang, Erik Y. Zhang, Jenna Green, Emily P. Martin, Grace A. Wikenheiser, Kathryn A. Wikenheiser‐Brokamp, Anne‐Karina T. Perl, Debora I. Sinner, Jane J. Yu, Yan Xu
This study identifies two distinct LAM subtypes and their microenvironmental interactions using multi-omics and spatial transcriptomics, revealing key regulatory networks and potential therapeutic targets.
European Respiratory Journal · Jun 25, 2026Peer-reviewedGenomics