Debora I. Sinner

This study identifies two distinct LAM subtypes and their microenvironmental interactions using multi-omics and spatial transcriptomics, revealing key regulatory networks and potential therapeutic targets.

The paper shows that the ARID1A-containing BAF complex is essential for lung development, proximal-distal axis specification, and cell fate acquisition during respiratory development.

This study investigates the role of Notum and Wnt5a in regulating the timing of cartilaginous mesenchymal condensations in developing trachea, showing their impact on chondrogenesis and tracheal lumen formation.

This study shows that Wnt signaling regulates ion channel expression, which is essential for trachealis muscle and cartilage development in mice.

This study identifies a SNP that affects Wnt4 expression in endometrial stroma, linking it to pregnancy, endometriosis, and reproductive cancers through differential gene regulation.

The paper identifies six distinct basal cell subpopulations in the murine trachea, showing regional differences in their stemness and response to injury, with conservation in humans.

The paper identifies PI3K signaling's role in regulating SOX9+ lung progenitor cell fate through gene regulatory networks using RNA-Seq and ATAC-Seq data.

This study identifies a HH-Foxf1-Rspo2 signaling axis critical for tracheal cartilage development and shows its disruption leads to tracheomalacia.