Endothelial PTBP1 Deletion in Transplanted Cardiac Tissue Limits Cardiac Allograft Vasculopathy
Christopher L. Pathoulas, Koki Hayashi, Ivy A. Rosales, Amy L. Kimble, Krish C. Dewan, Ryan T. Gross, Jenna Lancey, Lifang Ye, Qian Li, Y. Li, Bing Hao, Bo Reese, Evan R. Jellison, Antoine Ménoret, Anthony T. Vella, , Patrick A. Murphy
This study identifies PTBP1 as a key regulator of endothelial dysfunction in cardiac allograft vasculopathy, showing its deletion reduces fibrosis and immune activation in mouse models.
bioRxiv · Feb 19, 2026 · PreprintImmunology