Glycation-lowering compounds inhibit ghrelin signaling to reduce food intake, lower insulin resistance, and extend lifespan.
Lauren A. Wimer, Kiyomi Raye Kaneshiro, Jessica Ramirez, Neelanjan Bose, Martín Valdearcos, Muniesh Muthaiyan Shanmugam, Dominique O Farrera, Parminder Pal Singh, Jennifer Beck, Durai Sellegounder, Lizbeth Enriquez Najera, Simon Melov, Lisa Ellerby, Soo‐Jin Cho, John C. Newman, , Pankaj Kapahi
Gly-Low compounds reduce glycation, lower food intake, improve insulin sensitivity, and extend lifespan in mice by inhibiting ghrelin signaling and enhancing mTOR pathways.
Cell Reports · Oct 1, 2025Peer-reviewedMolecular Biology