Simon Melov

The human ovary exhibits dynamic molecular remodeling in the decades post-menopause

This study identifies age-related molecular changes in postmenopausal ovaries using proteomics, revealing dynamic remodeling and new biological insights.

Advanced Open-Source Experimental-Design Tools for Microplate-Based Assays with Acoustic Liquid Handling

The paper introduces PickliPy, an open-source framework for converting assay designs into ADE picklists, enabling reproducible and scalable microplate-based experiments.

Single-nucleus profiling reveals age-associated remodeling opposed by parity in the postmenopausal human ovary

The paper uses single-nucleus profiling to show age-related changes in the postmenopausal ovary, which are counteracted by parity.

Proteogenomic Profiling Reveals a Distinct Endogenous p16INK4a-Associated Senescence Signature in the Human Ovary.

The paper identifies a distinct p16INK4a-associated senescence signature in human ovarian tissue through proteogenomic profiling and spatial analysis.

Senescence-Linked Fibrosis in the Aging Human Ovary Revealed by p16-Based Histological Profiling and Spatial Transcriptomics

The paper identifies and maps senescent cells in postmenopausal ovaries using p16 expression and spatial transcriptomics, revealing a fibro-inflammatory signature associated with aging.

Cellular Senescence Mediates Doxorubicin Chemotherapy-Induced Vascular Endothelial Dysfunction: Translational Evidence of Prevention with Senolytic Treatment

This study shows that cellular senescence contributes to Doxorubicin-induced vascular endothelial dysfunction and that senolytic treatment can prevent this dysfunction.

Glycation-lowering compounds inhibit ghrelin signaling to reduce food intake, lower insulin resistance, and extend lifespan.

Gly-Low compounds reduce glycation, lower food intake, improve insulin sensitivity, and extend lifespan in mice by inhibiting ghrelin signaling and enhancing mTOR pathways.

Cellular Senescence Mediates Doxorubicin Chemotherapy-Induced Aortic Stiffening: Role of Glycation Stress

This study shows that doxorubicin chemotherapy induces aortic stiffening via cellular senescence and the senescence-associated secretory phenotype, which can be mitigated by senolytic therapy.

A comprehensive multi-omics signature of doxorubicin-induced cellular senescence in the postmenopausal human ovary.

The paper establishes a senotype of doxorubicin-induced senescence in postmenopausal human ovarian tissue using single nuclei sequencing and proteomics.

Transcriptomic Characterization Reveals Disrupted Medium Spiny Neuron Trajectories in Huntington's Disease and Possible Therapeutic Avenues

The paper uses single-cell RNA sequencing to study Huntington's disease by analyzing medium spiny neuron development in HD iPSC models and identifies potential therapeutic molecules.

Dietary restriction and clock delay eye aging to extend lifespan in D. melanogaster

This study shows dietary restriction extends lifespan in D. melanogaster by protecting the visual system from age and light-related damage through circadian regulation.