This study shows curcumin and sulforaphane improve mobility in aging C. elegans through distinct transcriptional mechanisms, with their combination enhancing detoxification and reducing immune gene expression.

bioRxiv · Jun 25, 2026 · PreprintSystems Biology

Glycation-lowering compounds inhibit ghrelin signaling to reduce food intake, lower insulin resistance, and extend lifespan.

Lauren A. Wimer, Kiyomi Raye Kaneshiro, Jessica Ramirez, Neelanjan Bose, Martín Valdearcos, Muniesh Muthaiyan Shanmugam, Dominique O Farrera, Parminder Pal Singh, Jennifer Beck, Durai Sellegounder, Lizbeth Enriquez Najera, Simon Melov, Lisa Ellerby, Soo‐Jin Cho, John C. Newman, , Pankaj Kapahi

Gly-Low compounds reduce glycation, lower food intake, improve insulin sensitivity, and extend lifespan in mice by inhibiting ghrelin signaling and enhancing mTOR pathways.

Cell Reports · Oct 1, 2025Peer-reviewedMolecular Biology

Pathogenic tau inhibits synaptic plasticity by blocking eIF4B-mediated local protein synthesis

Grant Kauwe, Doyle Lokitiyakul, Ivy L. Wong, Kevin Schneider, Varun Sridhar, Durai Sellegounder, Yani Y. Ngwala, Lei Yao, Jackson H. Chen, Kristeen A. Pareja-Navarro, Alissa L. Nana, Salvatore Spina, William W. Seeley, Lea T. Grinberg, Eric M. Verdin, , Tara E. Tracy

bioRxiv · Sep 11, 2025 · PreprintNeuroscience

Methylglyoxal-derived hydroimidazolone, MG-H1, increases food intake by altering tyramine signaling via the GATA transcription factor ELT-3 in Caenorhabditis elegans

Muniesh Muthaiyan Shanmugam, Jyotiska Chaudhuri, Durai Sellegounder, Amit Kumar Sahu, Sanjib K Guha, Manish Chamoli, Brian A. Hodge, Neelanjan Bose, Charis Amber, Dominique O Farrera, Gordon J. Lithgow, Richmond Sarpong, James J. Galligan, Pankaj Kapahi

This study identifies MG-H1 as a mediator of increased food intake in C. elegans glod-4 mutants through a tyramine signaling pathway regulated by the GATA transcription factor ELT-3.

eLife · Sep 20, 2023Peer-reviewedGenetics