Jenny L. Littler

Biofilm-deficient mutants of Pseudomonas aeruginosa have wild-type levels of antibiotic tolerance in a model of cystic fibrosis lung infection

This study shows that biofilm-deficient Pseudomonas aeruginosa mutants have wild-type antibiotic tolerance in a cystic fibrosis lung model, suggesting other mechanisms, like efflux pumps, are sufficient for tolerance.

Transfer learning enables discovery of sub-micromolar antibacterials for ESKAPE pathogens from ultra-large chemical spaces

This paper uses transfer learning to identify potent antibacterials from large chemical libraries, finding 54% of tested compounds active against E. coli with sub-micromolar potency.