Jonathan Whiteside

This paper introduces a new cyclisation strategy using a bromomethyl picolinaldehyde linker to expand macrocyclic peptide topologies, leading to more potent and diverse inhibitors.

The paper identifies and optimizes bicyclic peptide inhibitors of Staphylococcus aureus α-hemolysin, achieving sub-micromolar affinity and demonstrating functional inhibition of toxin activity.

This paper uses transfer learning to identify potent antibacterials from large chemical libraries, finding 54% of tested compounds active against E. coli with sub-micromolar potency.