Freya Harrison

This paper investigates the multifaceted antibacterial mechanisms of Bald's eyesalve against S. aureus and A. baumannii, showing its potential as a multi-target antimicrobial.

This study shows that tEDTA disrupts Pseudomonas aeruginosa membranes, suppresses resistance evolution, and has lower cytotoxicity than meropenem.

This study shows that biofilm-deficient Pseudomonas aeruginosa mutants have wild-type antibiotic tolerance in a cystic fibrosis lung model, suggesting other mechanisms, like efflux pumps, are sufficient for tolerance.

This study evaluates the efficacy of tetrasodium EDTA against P. aeruginosa biofilms in different infection models, finding it effective in chronic wound and CF lung infections but not in endotracheal tube colonization.

The paper tracks eco-evolutionary dynamics in lung pathobiomes of children with cystic fibrosis, finding that P. aeruginosa variants reduce antagonism towards other pathogens, potentially stabilizing communities.

This study identifies BatR as a regulator of biofilm formation and antibiotic tolerance in Pseudomonas aeruginosa, showing its interaction with SrkA and role in eDNA release and pyocyanin production.

This paper introduces an in vitro model of endotracheal tube biofilms that demonstrates the effectiveness of combining matrix-degrading enzymes with antimicrobials to eradicate pathogens causing ventilator-associated pneumonia.

This study identifies PA3049, renamed BatR, as a key regulator of antibiotic tolerance in Pseudomonas aeruginosa biofilms, showing its role in stress response and antimicrobial resistance.

This study investigates how environmental factors influence the evolutionary consequences of siderophore loss in Pseudomonas aeruginosa, showing that genotype-environment interactions determine whether siderophore mutants cheat, suffer fitness defects, or have no effect.

This study uses meta-analysis to assess the role of pyoverdine, a virulence factor in Pseudomonas aeruginosa, across different infection models, finding its effect varies significantly and is rarely essential for infections.