Author

Emily J. Geddes

Broad InstituteORCID 0000-0002-7756-1792Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Research Focus:benchmarking· 1 Organism:E. coli· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Andreas BenderiD· 1 shared Austin N. BondiD· 1 shared Carl Edward RasmusseniD· 1 shared Collette S. GuyiD· 1 shared Cong LiuiD· 1 shared Deborah Tan HungiD· 1 shared Diana K. HuntiD· 1 shared James E. GomeziD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperBioinformatics

Andreas BenderORCID

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2 papers

Recent·Most cited

MicrobiologyACS Infectious DiseasesPeer-reviewedMay 13, 2026

Large-Scale Chemical-Genetic Interaction Profiling Identifies a Novel Small-Molecule Inhibitor of Mycobacterium tuberculosis Polyketide Synthase 13

James E. Gomez, Matthew Y. Solomon, Diana K. Hunt…·Deborah Tan Hung

This paper identifies a novel small-molecule inhibitor of Mycobacterium tuberculosis Pks13 through chemical-genetic interaction profiling and validates its mechanism of action.

DOI 10.1021/acsinfecdis.6c00136

humanproteomics

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BioinformaticsChemical SciencePeer-reviewedJan 1, 2025

Transfer learning enables discovery of sub-micromolar antibacterials for ESKAPE pathogens from ultra-large chemical spaces

Miguel García-Ortegón, Srijit Seal, Emily J. Geddes…·Sergio Bacallado

This paper uses transfer learning to identify potent antibacterials from large chemical libraries, finding 54% of tested compounds active against E. coli with sub-micromolar potency.

4 citations

E. colideep learning

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