Schuyler M. Melore

The paper identifies SMARCA2 as a critical cofactor for a subset of glucocorticoid response genes in A549 cells through a CRISPR screen and functional analysis.

This paper introduces a CRISPRi system using dHyperLbCas12a for highly multiplexed epigenome editing and demonstrates its application in proliferation and CRE analysis screens.

The paper develops a multiplex reverse genetics platform to identify genetic modifiers of protein misfolding in neurodegenerative diseases and identifies DNAJB6 as a modifier of toxicity and solubility of ALS/FTD-linked RNA-binding proteins.