Circulatory proteins shape microglia state and boost phagocytosis
Nannan Lu, Patricia Morán Losada, Oliver Hahn, Aryaman Saksena, Emma Tapp, Jean Paul Chadarevian, Wentao Dong, Sophia M. Shi, Steven R. Shuken, Ian Hunter Guldner, Wenshu Zeng, Ning-Sum To, Pui Shuen Wong, Jonathan Hasselmann, Hayk Davtyan, , Tony Wyss‐Coray
The paper identifies a microglia population that takes up circulatory proteins, enhancing phagocytosis and innate immunity through ApoA-I uptake.
bioRxiv · Sep 30, 2024 · PreprintNeuroscience