Nannan Lu

The paper uses plasma proteomics to estimate biological age of multiple cell types and links aging signatures to disease risk and mortality across 60,000 individuals.

The paper identifies microglial states and activation genes in aging and parabiosis, revealing region-specific responses and vulnerabilities in the brain.

The paper investigates age-related changes in cerebellar microglia using single-nuclei RNA sequencing and MERFISH, finding enhanced neuroprotective immune activation and proximity to granule cells in aged mice.

The paper identifies neuronal proteins that degrade slower with aging and accumulate in microglia, linking impaired synaptic protein turnover to age-related cognitive decline.

The paper creates a spatio-temporal miRNA atlas in mice, identifying age-related miR-155-5p increase driven by microglia, independent of sex.

The paper identifies a microglia population that takes up circulatory proteins, enhancing phagocytosis and innate immunity through ApoA-I uptake.

This study identifies PTER as the taurine N-acetyltransferase/hydrolase, showing its role in regulating N-acetyltaurine levels and linking it to energy balance and metabolic phenotypes.

This study identifies molecular foci of brain aging in mice using spatiotemporal RNA-seq, showing accelerated glial aging in white matter and differential gene expression linked to neurodegenerative diseases.

The paper analyzes single-nucleus transcriptomes from brain and choroid plexus tissues of COVID-19 and influenza patients, identifying broad transcriptional dysregulation in multiple cell types and linking these changes to neurological symptoms.

This study shows that blood vessel regression in the brain reduces neuronal activity by impairing mitochondrial metabolism and glutamate production.