Ian Hunter Guldner

The paper maps age-related changes in the N-glycoproteome across multiple tissues in mice, showing how glycosylation affects autoantibody binding to MOG in the brain.

This study identifies sex-dimorphic molecular responses to microglial depletion in aged mice, highlighting differences in transcriptional and proteomic changes between males and females.

This study identifies age- and sex-related changes in the mouse myelin proteome, revealing increased structural proteins and decreased cytoskeletal and synaptic proteins with aging.

The paper creates a multi-tissue transcriptomic aging atlas in killifish, identifies age-altered pathways, and develops tissue-specific transcriptomic clocks with sex-specific biomarkers for aging prediction.

The paper identifies neuronal proteins that degrade slower with aging and accumulate in microglia, linking impaired synaptic protein turnover to age-related cognitive decline.

The paper creates a spatio-temporal miRNA atlas in mice, identifying age-related miR-155-5p increase driven by microglia, independent of sex.

CSF YWHAG:NPTX2 synapse protein ratio, from proteomics of 3,416 individuals across six cohorts, explains cognitive impairment beyond amyloid and tau and predicts decline (hazard ratio 15.4).

The paper identifies a microglia population that takes up circulatory proteins, enhancing phagocytosis and innate immunity through ApoA-I uptake.

This study identifies molecular foci of brain aging in mice using spatiotemporal RNA-seq, showing accelerated glial aging in white matter and differential gene expression linked to neurodegenerative diseases.

The paper links APOE4/4 genotype to lipid droplet accumulation in Alzheimer's microglia, showing its role in neurotoxicity through triglyceride synthesis and Tau phosphorylation.

This paper introduces instant FLIM, a real-time fluorescence lifetime imaging method, and demonstrates its application in long-term in vivo brain imaging in zebrafish and mice.