Structure and functional diversity of antibodies targeting the P. falciparum circumsporozoite protein C-terminal domain
Re’em Moskovitz, Iszac Burton, Nathan Beutler, Gonzalo Ernesto González-Páez, Thea R. Zalunardo, Michael Bick, Justin Ndihokubwayo, Kiara Gambuzza, Jerry Zhao, Robyn L. Stanfield, Xueyong Zhu, Monika Jain, Elizabeth A. Winzeler, Daniel E. Emerling, Christian F. Ockenhouse, , Ian A. Wilson
This study characterizes the structure and function of antibodies targeting the conserved β-epitope region of PfCSP, showing how they achieve strain-transcending recognition and enhance Fc-mediated immune responses.
bioRxiv · Jun 8, 2026 · PreprintMicrobiology