LC8 enhances 53BP1 foci through heterogeneous bridging of 53BP1 oligomers
Jesse Howe, Douglas R. Walker, Kyle Tengler, Maya Sonpatki, Patrick N. Reardon, Justin W. C. Leung, Elisar J. Barbar
This study shows that LC8 bridges 53BP1 trimers to enhance 53BP1 foci formation, which is critical for DNA repair.
eLife · Apr 29, 2025Peer-reviewedBiophysics