Douglas R. Walker

The paper shows how LC8 converts the disordered KANK1 linker into a rod-like structure through cooperative multivalency, resolving a cellular architecture paradox.

This paper characterizes a seven-state binding network in dynein assembly using 39 ITC experiments and Bayesian inference, revealing previously unrecognized binding states and balancing cooperativities.

This paper improves Bayesian parameter inference for ITC by resolving prior ambiguity through multi-dataset analysis and hierarchical modeling, enhancing accuracy in binding parameter estimation.

This study shows that LC8 bridges 53BP1 trimers to enhance 53BP1 foci formation, which is critical for DNA repair.

This paper designs a collagen heterotrimer with high folding specificity and reports its faster folding rate compared to other systems.