Elisar J. Barbar

Cooperative multivalency converts disorder into rods, resolving a paradox in cellular architecture

The paper shows how LC8 converts the disordered KANK1 linker into a rod-like structure through cooperative multivalency, resolving a cellular architecture paradox.

Walking the Tightrope: Balancing Opposing Cooperativities as an Operating Principle in Dynein Assembly.

This paper characterizes a seven-state binding network in dynein assembly using 39 ITC experiments and Bayesian inference, revealing previously unrecognized binding states and balancing cooperativities.

Improving parameter inference by resolving Bayesian prior ambiguity via multi-dataset analysis: Application to isothermal titration calorimetry

This paper improves Bayesian parameter inference for ITC by resolving prior ambiguity through multi-dataset analysis and hierarchical modeling, enhancing accuracy in binding parameter estimation.

LC8 enhances 53BP1 foci through heterogeneous bridging of 53BP1 oligomers

This study shows that LC8 bridges 53BP1 trimers to enhance 53BP1 foci formation, which is critical for DNA repair.

Dimerisation of the PICTS complex via LC8/Cut-up drives co-transcriptional transposon silencing in Drosophila

This study identifies LC8/Cut-up as an essential component of the PICTS complex in Drosophila, showing its role in transposon silencing through complex dimerisation.