Combinations of approved oral nucleoside analogues confer potent suppression of alphaviruses in vitro and in vivo
Sam Verwimp, Jessica Wagoner, Elijah Gabriela Costales Arenas, Lander De Coninck, Rana Abdelnabi, Jennifer Hyde, Joshua Tisdell Schiffer, Judith M. White, Jelle Matthijnssens, Johan H. Neyts, Stephen J. Polyak, Leen Delang
This study evaluates combinations of approved oral nucleoside analogues against multiple alphaviruses in vitro and in vivo, finding synergistic antiviral effects and reduced viral mutation rates with combination therapy.
Antiviral Research · May 14, 2025Peer-reviewedMicrobiology