Stephen J. Polyak

This study evaluates combinations of approved oral nucleoside analogues against multiple alphaviruses in vitro and in vivo, finding synergistic antiviral effects and reduced viral mutation rates with combination therapy.

The paper determines the molecular mechanism of VP0 cleavage in enteroviruses using structural and bioinformatic analysis of a provirion intermediate.

The paper identifies host proteins modulating SARS-CoV-2 infection by expanding the virus-host protein interaction network and testing chemical inhibitors of these targets.