Jennifer Hyde

This study shows TAK1 activates the NLRP1 inflammasome in response to dsRNA, linking it to inflammatory responses in viral infection and autoimmunity.

This study evaluates combinations of approved oral nucleoside analogues against multiple alphaviruses in vitro and in vivo, finding synergistic antiviral effects and reduced viral mutation rates with combination therapy.

This study identifies RNA structures in the E1 gene of epizootic VEEV that alter macrophage replication fitness, suggesting RNA secondary structures contribute to viral emergence.

This paper creates a mouse model of pegivirus infection and investigates immune mechanisms of persistence and cross-species infection.