Author

Congxin Li

German Cancer Research CenterORCID 0000-0002-9731-4297Unclaimed ORCID profile · follow to get notified of new preprints

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Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:clustering· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Thomas HöferiD· 3 shared Alejo Rodriguez-FraticelliiD· 1 shared Alessandro GrecoiD· 1 shared Alexander GerbauletiD· 1 shared Amit SinghiD· 1 shared Anastasia SedlmeieriD· 1 shared Andreas DahliD· 1 shared Andreas TrumppiD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersSystems Biology

Thomas HöferORCID

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4 papers

Recent·Most cited

A kinetics-based model of hematopoiesis reveals extrinsic regulation of skewed lineage output from stem cells

Esther Rodriguez-Correa, Florian Grünschläger, Tamar Nizharadze, Natasha Anstee, Jude Al-Sabah, Vojtěch Kumpošt, Anastasia Sedlmeier, Congxin Li, Melanie Ball, Foteini Fotopoulou, Jeyan Jayarajan, Ian Ghezzi, Julia Knoch, Megan Druce, Kleo Aurich, , Michael D. Milsom

This study uses single-cell transplantation and mathematical modeling to show that lineage biases in hematopoiesis arise from extrinsic feedback and clonal competition, not intrinsic HSC properties.

Nature Cell Biology · May 25, 2026Peer-reviewedCell Biology

Coordinated alternative splicing decisions via stepwise exon definition

Panajot Kristofori, Zijie Xiao, Simon Braun, Anke Busch, Kathi Zarnack, Julian König, Stefan Legewie, Congxin Li

The paper shows that intron retention and alternative exon choice are coupled through multistep exon recognition by the spliceosome, which is disrupted in cancer.

Nucleic Acids Research · May 1, 2026Peer-reviewedSystems Biology

Data-driven modelling captures dynamics of the circadian clock ofNeurospora crassa

Amit Singh, Congxin Li, Axel C. R. Diernfellner, Thomas Höfer, Michael Brunner

The paper develops a data-driven model of the circadian clock in Neurospora crassa using luciferase reporter data to estimate parameters and reveal the role of FRQ maturation in circadian rhythms.

PLoS Computational Biology · Aug 11, 2022Peer-reviewedSystems Biology

Hematopoietic lineages diverge within the stem cell compartment

Mina N.F. Morcos, Congxin Li, Clara M. Munz, Alessandro Greco, Nicole Dressel, Susanne Reinhardt, Katrin Sameith, Andreas Dahl, Nils B. Becker, Axel Roers, Thomas Höfer, Alexander Gerbaulet

The paper uses fate-mapping, single-cell RNA-sequencing, and computational methods to show that major hematopoietic lineages diverge within HSCs, identifying a self-renewing HSC subpopulation and a direct thrombopoiesis pathway.

Nature Communications · Aug 3, 2022Peer-reviewedSystems Biology