Jin Chen

This study identifies ARG2 deficiency in tumor cells as a driver of lung metastasis via NOS2-dependent Th17 responses in immune-competent hosts.

The paper identifies CPT1A loss as a driver of lung metastasis in immune-competent mice through mtDNA release and STING pathway activation, with clinical relevance in breast cancer.

This study shows targeting mTORC2 in lung squamous cell carcinoma enhances anti-tumor immunity via the PSGL-1-VISTA axis by altering the tumor microenvironment and immune cell activation.

This study identifies a mechanism by which tumor endothelium regulates fatty acid delivery to metastases, showing that mTORC1 inhibition in endothelial cells reduces metastatic disease by impairing T cell fatty acid uptake.