Author

Deanna N. Edwards

Vanderbilt UniversityORCID 0000-0001-5481-5879Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Assay:bulk RNA-seq· 3 Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 2 Approach:genetic perturbation / CRISPR· 2 Research Focus:cell-cell communication· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Jin CheniD· 4 shared Yoonha HwangiD· 4 shared Shu-Ting ChouiD· 2 shared Verra M. NgwaiD· 2 shared Wenqiang SongiD· 2 shared Xiaoyong WangiD· 2 shared Jeffrey C. RathmelliD· 1 shared Jiacheng Wang· 1 shared

Activity by Year

2025-2026 · peak 2/yr

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10 top collaborators · 30 mutual co-author links

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4 shared papersCancer Biology

Jin ChenORCID

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4 papers

Recent·Most cited

Loss of Arginase 2 Promotes Lung Metastasis in immune-competent hosts via Nitric Oxide Synthase 2-Dependent Th17 Response

Shu-Ting Chou, Xiaoyong Wang, Jing Yang, Yoonha Hwang, Jiacheng Wang, Yujie Ding, Jeffrey C. Rathmell, Deanna N. Edwards, Jin Chen

This study identifies ARG2 deficiency in tumor cells as a driver of lung metastasis via NOS2-dependent Th17 responses in immune-competent hosts.

bioRxiv · Jun 8, 2026 · PreprintCancer Biology

CPT1A loss promotes lung metastasis in immune-competent mice via a mechanism of mtDNA release and chronic activation of STING pathway

Xiaoyong Wang, Shu-Ting Chou, Yoonha Hwang, Jin Chen, Deanna N. Edwards

The paper identifies CPT1A loss as a driver of lung metastasis in immune-competent mice through mtDNA release and STING pathway activation, with clinical relevance in breast cancer.

bioRxiv · May 5, 2026 · PreprintCancer Biology

Targeting mTORC2 in lung squamous cell carcinoma improves anti-tumor immunity through the PSGL-1-VISTA axis

Verra M. Ngwa, Yoonha Hwang, Wenqiang Song, Deanna N. Edwards, Jin Chen

This study shows targeting mTORC2 in lung squamous cell carcinoma enhances anti-tumor immunity via the PSGL-1-VISTA axis by altering the tumor microenvironment and immune cell activation.

Cancer Gene Therapy · Jul 10, 2025Peer-reviewedCancer Biology

Regulation of fatty acid delivery to metastases by tumor endothelium

Deanna N. Edwards, Shan Wang, Kelby M. Kane, Wenqiang Song, Laura C. Kim, Verra M. Ngwa, Yoonha Hwang, Kevin C. Ess, Mark Robin Boothby, Jin Chen

This study identifies a mechanism by which tumor endothelium regulates fatty acid delivery to metastases, showing that mTORC1 inhibition in endothelial cells reduces metastatic disease by impairing T cell fatty acid uptake.

JCI Insight · Apr 8, 2025Peer-reviewedCancer Biology