CHMP2B regulates TDP-43 phosphorylation and proteotoxicity via modulating CK1 turnover independent of the autophagy-lysosomal pathway
Xue Deng, Xing Sun, Wenkai Yue, Yongjia Duan, Rirong Hu, Kai Zhang, Jiangxia Ni, Jihong Cui, Qiangqiang Wang, Yelin Chen, Ang Li, Yanshan Fang
This study identifies CHMP2B as a regulator of TDP-43 phosphorylation and proteotoxicity through CK1 turnover, independent of autophagy-lysosomal pathways in neurodegenerative diseases.
The Journal of Cell Biology · Oct 5, 2021Peer-reviewedNeuroscience