Author

Maren Pein

University of California, IrvineORCID 0000-0002-7906-5960Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:human· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

Delia F. TifreaiD· 2 shared Devon A. LawsoniD· 2 shared Kai KessenbrockiD· 2 shared Robert A. EdwardsiD· 2 shared Sharmila MallyaiD· 2 shared Aaron J. LongworthiD· 1 shared Aaron SimoniD· 1 shared Aatish ThennavaniD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCancer Biology

Delia F. TifreaORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Single-cell profiling of synchronous multi-organ metastasis reveals a systemic CD74+ lipid-associated macrophage niche driving polymetastatic breast cancer

Jacob Insua‐Rodríguez, Pascal Naef, Hannah Savage, Isam Adam, Sung Kook Chun, Axel A. Almet, Gautham Prabhakar, Sharon Kwon, Cassandra G Sweet, Sevilla Farah Hennessey, Angela Lincy Prem Antony Samy, Hamad S. Alshetaiwi, Maren Pein, Sharmila Mallya, Delia F. Tifrea, , Devon A. Lawson

This study identifies a conserved CD74+ macrophage niche driven by MIF-CD74 signaling that supports multi-organ metastasis in breast cancer and shows its therapeutic targeting reduces metastatic burden.

bioRxiv · Feb 3, 2026 · PreprintCancer Biology

A spatially resolved single cell genomic atlas of the adult human breast

Tapsi Kumar, Kevin Nee, Runmin Wei, Siyuan He, Quy Nguyen, Shanshan Bai, Kerrigan Blake, Maren Pein, Yanwen Gong, Emi Sei, Min Shan Hu, Tod D. Casasent, Aatish Thennavan, Jianzhuo Li, Tuan Tran, , Nicholas E. Navin

This paper constructs a comprehensive spatially resolved single-cell genomic atlas of the adult human breast, identifying 11 major cell types and revealing diverse immune and epithelial cell populations.

Nature · Jun 28, 2023Peer-reviewedGenomics