Aatish Thennavan

Trp53 heterozygosity defines novel states impacting tumor plasticity and progression in Kras-initiated non-small cell lung cancer

This study shows that TP53 heterozygosity in Kras-mutant lung cancer affects tumor plasticity and progression, with distinct genomic and survival outcomes compared to complete TP53 loss.

Defining the Regulatory Logic of Breast Cancer Using Single-Cell Epigenetic and Transcriptome Profiling

This study identifies regulatory elements that switch from silencers to enhancers in breast cancer cells using single-cell ATAC-seq and RNA-seq data.

Single-Cell Transcriptional and Epigenetic Profiles of Male Breast Cancer Nominate Salient Cancer-Specific Enhancers

This study presents single-cell transcriptional and epigenetic profiles of male breast cancer to identify cancer-specific enhancers and their regulatory roles.

Conserved Chamber-Specific Polyploidy Maintains Heart Function in Drosophila

This study identifies conserved polyploidy asymmetry between cardiac chambers in Drosophila and humans, showing its role in maintaining heart function and its implications for heart failure.

A spatially resolved single cell genomic atlas of the adult human breast

This paper constructs a comprehensive spatially resolved single-cell genomic atlas of the adult human breast, identifying 11 major cell types and revealing diverse immune and epithelial cell populations.

SCDC: Bulk Gene Expression Deconvolution by Multiple Single-Cell RNA Sequencing References

SCDC improves bulk RNA-seq deconvolution by integrating multiple scRNA-seq reference datasets, achieving better accuracy in cell-type decomposition.