Author

Jiayi E. Wang

University of ChicagoPrimary ORCID profile (0009-0009-1818-3670 · 2 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Jiayi E. WangiD2 papers · University of Chicago

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Charanya MuralidharaniD· 2 shared Jacob R. EnriqueziD· 2 shared Kerim B. KaylaniD· 2 shared Raghavendra G. MirmiraiD· 2 shared Sarah A. TerseyiD· 2 shared Sarah C. MayiD· 2 shared Titli NargisiD· 2 shared Abhishek KulkarniiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersMolecular Biology

Charanya MuralidharanORCID

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2 papers

Recent·Most cited

The G protein-coupled receptor GPR31 governs inflammatory signaling in the pancreatic islet microenvironment

Kerim B. Kaylan, Xia S. Saavedra, Christian Checkcinco, Jacob R. Enriquez, Titli Nargis, Emily Elliot, Armando A. Puente, Jiayi E. Wang, Melissa Walsh, Jennifer Nelson, Abhishek Kulkarni, Charanya Muralidharan, Sarah C. May, Ryan M. Anderson, Raghavendra G. Mirmira, Sarah A. Tersey

This study identifies GPR31 as a key inflammatory regulator in pancreatic islets, showing its role in β-cell stress and macrophage activation in type 1 diabetes.

bioRxiv · Oct 2, 2025 · PreprintMolecular Biology

12-Lipoxygenase inhibition delays onset of autoimmune diabetes in human gene replacement mice

Titli Nargis, Charanya Muralidharan, Jacob R. Enriquez, Jiayi E. Wang, Kerim B. Kaylan, Advaita Chakraborty, Sarida Pratuangtham, Kayla T. Figatner, Jennifer B. Nelson, Sarah C. May, Jerry L. Nadler, Matthew B. Boxer, David J. Maloney, Sarah A. Tersey, Raghavendra G. Mirmira

This study shows that inhibiting 12-LOX with VLX-1005 delays autoimmune diabetes onset in human gene replacement mice by altering inflammatory pathways and immune cell infiltration.

JCI Insight · Nov 12, 2024Peer-reviewedMolecular Biology