Author

Kayla T. Figatner

University of Chicago

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Molecular Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:metabolism & bioenergetics· 2 Assay:proteomics· 2 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Raghavendra G. MirmiraiD· 4 shared Sarah A. TerseyiD· 4 shared Sarida PratuangthamiD· 4 shared Advaita Chakraborty· 3 shared David J. MaloneyiD· 2 shared Jacob R. EnriqueziD· 2 shared Jerry L. NadleriD· 2 shared Kerim B. KaylaniD· 2 shared

Activity by Year

2024-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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4 shared papersCell Biology

Raghavendra G. MirmiraORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Islet-intrinsic sex differences in inflammatory signaling contribute to autoimmune diabetes susceptibility

Kierstin L. Webster, Armando A. Puente, Jacob R. Enriquez, Soumyadeep Sarkar, Ernesto Satoshi Nakayasu, Bobbie‐Jo Webb‐Robertson, Lisa Bramer, Kayla T. Figatner, Sarida Pratuangtham, Wenting Wu, Carmella Evans‐Molina, Hubert Ming Tse, Saptarshi Roy, Jon D. Piganelli, Stephen R. Hammes, , Raghavendra G. Mirmira

This study identifies sex-specific islet responses to inflammation and shows that estrogen reduces inflammatory signaling and promotes immune tolerance in beta cells, contributing to sex differences in type 1 diabetes susceptibility.

bioRxiv · Oct 6, 2025 · PreprintCell Biology

Hypusinated and unhypusinated isoforms of eIF5A exert distinct effects in models of pancreas development and function

Cara M. Anderson, Abhishek Kulkarni, Bernhard Maier, Fei Huang, Kayla T. Figatner, Advaita Chakraborty, Sarida Pratuangtham, Sarah C. May, Sarah A. Tersey, Ryan M. Anderson, Raghavendra G. Mirmira

This study investigates the distinct roles of hypusinated and unhypusinated eIF5A isoforms in pancreas development and function using zebrafish and mouse models.

Journal of Biological Chemistry · Jan 18, 2025Peer-reviewedCell Biology

12-Lipoxygenase inhibition improves glucose homeostasis and obesity-associated inflammation in human gene replacement mice

Kerim B. Kaylan, Titli Nargis, Kayla T. Figatner, Jiayi E. Wang, Sarida Pratuangtham, Advaita Chakraborty, Isabel Casimiro, Jerry L. Nadler, Matthew B. Boxer, David J. Maloney, Ryan M. Anderson, Raghavendra G. Mirmira, Sarah A. Tersey

This study shows that inhibiting 12-LOX improves glucose homeostasis and reduces obesity-related inflammation in human gene replacement mice.

bioRxiv · Jan 10, 2025 · PreprintPhysiology

12-Lipoxygenase inhibition delays onset of autoimmune diabetes in human gene replacement mice

Titli Nargis, Charanya Muralidharan, Jacob R. Enriquez, Jiayi E. Wang, Kerim B. Kaylan, Advaita Chakraborty, Sarida Pratuangtham, Kayla T. Figatner, Jennifer B. Nelson, Sarah C. May, Jerry L. Nadler, Matthew B. Boxer, David J. Maloney, Sarah A. Tersey, Raghavendra G. Mirmira

This study shows that inhibiting 12-LOX with VLX-1005 delays autoimmune diabetes onset in human gene replacement mice by altering inflammatory pathways and immune cell infiltration.

JCI Insight · Nov 12, 2024Peer-reviewedMolecular Biology