A protein complex in the extreme distal tip of vertebrate motilecilia controls their organization, length, and function
Juyeon Hong, Chanjae Lee, Gopika Madhu, Ophelia Papoulas, Ece Atayeter, Gabriel Hoogerbrugge, Jiehong Pan, Maki Takagishi, Nadia I. Manzi, Daniel J. Dickinson, Amjad Horani, Steven L. Brody, Edward M. Marcotte, Vivek N. Prakash, Tae Joo Park, John B. Wallingford
The paper identifies two proteins, Ccdc78 and Ccdc33, at the distal tip of vertebrate motile cilia, showing they are essential for cilia organization, length regulation, and function.
Nature Communications · Dec 21, 2025Peer-reviewedCell Biology