Daniel J. Dickinson

This study shows that opposing actomyosin pools drive cortical flows to establish epithelial polarity in mouse embryonic stem cell spheroids.

The paper develops a toolkit of membrane-localising tags tested across ten animal species to identify effective signals for targeting proteins to the plasma membrane.

The paper identifies two proteins, Ccdc78 and Ccdc33, at the distal tip of vertebrate motile cilia, showing they are essential for cilia organization, length regulation, and function.

The paper measures mRNA translation in C. elegans embryos and identifies stage-specific translational regulation and the role of OMA-1 in repressing and promoting translation of target mRNAs.

This study shows how PAR-3/aPKC cooperativity establishes cell polarity in C. elegans zygotes through multivalent assembly, with PLK-1 regulating its downregulation during polarity maintenance.

This study identifies distinct roles of Aurora A in regulating PAR protein localization during different stages of the C. elegans cell cycle, explaining varied polarity phenotypes observed in RNAi experiments.

The paper shows that apical PAR-3 caps in C. elegans embryos orient the mitotic spindle independently of actomyosin and CDC-42, and work with aPKC to regulate spindle orientation.

The paper introduces new tools for the auxin-inducible degron system in C. elegans, enabling conditional protein depletion through CRISPR/Cas9-mediated genome editing.

This study investigates the role of RAP-1 in Ras-dependent cell fate decisions in C. elegans, showing it promotes fate induction and functions alongside LET-60/Ras.